Articles related to 'nmr screening'
December 18, 2012 // Pharmaceutical
Adulterated Natural Product Extract Detection - Viagra Derivatives
Detection of Adulterated Natural Product Extracts Containing Sildenafil (Viagra) Derivatives Kimberly L. Colson*, Sarah Luchsinger and Joshua M. Hicks, Bruker BioSpin, Billerica, MA USA The adulteration of natural products with sildenafil (Viagra), sulfoaildenafil, tadalafil, vardenafil or other derivatives is now a common problem. Equally common are the numerous attempts by adulterators to elude detection, such as regularly changing the supplied derivative in the natural product sample in the hope that the presence of such adulterants ... Continue reading
April 24, 2012 // Events
Wine Screening Solution Attracts Interest at ANUGA
The Bruker booth at this years Anuga FoodTec - an international trade fair for food and drink technology - was the location for the launch of the new NMR-based wine screening solution. As well as attendees of the show, selected customers in the German wine industry were invited to come along and discover for themselves how revolutionary the process could be to their existing methods. The first generation of the ... Continue reading
April 5, 2012 // Food Quality & Safety
Wine Safety and Quality Control using High-Resolution FT-NMR
Frequent wine scandals in recent years have demonstrated a need for a technology that can rapidly assess both quality and safety, yet be simple to use and deliver on a number of important parameters. A new solution performs wine analysis using proton NMR spectroscopy at 400 MHz, which includes straightforward sample preparation, rapid measurement and fully automated analysis, resulting in the simultaneous measurement of a set of key quality and safety relevant parameters. ... Continue reading
December 19, 2011 // Metabolomics
A New Perspective for the Future of Medicine Thanks to NMR Metabolomics
NMR has a great role to play in structural biology and in turn in systems biology. Its targets are proteins and nucleic acids. Small molecules in living beings, called metabolites, are an important chapter in systems biology and have always been markers of phenotypes and of health and disease. Metabolomics is the youngest of the omic sciences. It looks to define all metabolites in a specimen, i.e. a biological fluid, a tissue, a ... Continue reading
October 25, 2011 // Metabolomics
Imperial College, Real-Time Metabolic Profiling of Surgical Patients
Medical breakthroughs normally take a long time to reach a level where they are in common use, in fact 10 to 15 years is the norm. However, at the world’s first Centre for Surgical Metabonomics, a unique enterprise between Imperial College London and the Imperial College Healthcare NHS Trust, the focus is on translating new discoveries into new therapies as quickly as possible, namely the application of “molecular fingerprinting” technologies in a hospital setting to significantly improve surgical and therapeutic procedures. ... Continue reading
August 12, 2011 // Food Quality & Safety
Quality Validation of Food Analysis using non-targeted NMR screening
Customers who submit samples for analysis through the Bruker Analytical Services Food Center demand results of the highest quality and reliability, requiring continuous validation of analyses performed. An intensive in-house validation is undertaken as well as participation in official and international ring tests. For SGF-Profiling™ the following validation methods are continuously applied: Proof of highest-level reproducibility Proof of inter-instrumental identity of results Comparison with official ... Continue reading
August 10, 2011 // Pharmaceutical
Solving adulteration of pharmaceutical raw materials
Economically-driven adulteration in the pharmaceutical global supply chain has led to significant deaths in recent years. Over 100 deaths in 2007 from cough syrup adulterated with ethylene glycol, 81 deaths and several hundred injured from over-sulfated chondroitin led to a recall of Heparinue in 2008, and recent milk product adulteration with melamine that affected pet food and baby formula have placed the industry under the spotlight of scrutiny. The reasons are widespread; sourcing of raw material from ... Continue reading
August 1, 2011 // Food Quality & Safety
Dietary Supplements: Developing a ‘Fingerprinting’ Identification Tool
Efforts are underway to establish a non-targeted quality control screen for plant extracts used as dietary supplements. Such a screen will improve the safety and efficacy to the consumer and meet the 2007 FDA ruling requiring cGMP compliance to ensure the quality of dietary supplements. Raw material from plant vary widely due to agricultural, harvesting, or processing methods. Intentional adulteration or non-intentional adulteration may also occur in the commercial product. To add further confusion, plant material used in dietary supplements ... Continue reading
August 1, 2011 // Food Quality & Safety
High Throughput Push-button NMR in Fruit Juice Quality Control
SGF-Profiling is a unique quality control method for the authentication of fruit juices, based on Nuclear Magnetic Resonance (NMR) technology and enables the screening of apple and orange juices for origin authenticity, species purity or false labeling. Relying on an extensive spectroscopic database of NMR spectra from samples obtained from production sites all over the world, the unqiue database was generated in cooperation with SGF INTERNATIONAL E.V., SURE - GLOBAL - FAIR. The ... Continue reading
July 12, 2011 // Clinical Research
