This webinar was recorded on October 27, 2015.
The quantitative nature of NMR and the fact that it is structurally rich and non-intrusive makes the technique extremely useful to identify and characterise reaction intermediates, gain insights into the reaction mechanisms and determine kinetics. Vibrational spectroscopy, on the other hand, can be deployed to make in situ measurement in standard reactors and typically be used to define the reaction trajectories under realistic operational conditions in pilot or manufacturing sites.
What you will discover
While many chemical transformations have been analysed in regular NMR tubes, physical and chemical limits exist to the kinds of reactions to which this form of reaction monitoring is applicable. The lack of sufficient mixing, temperature control and pressure can have significant effects on the rate of a reaction. InsightMR, Bruker’s new solution for online reaction monitoring, circumvents these limitations.
InsightMR enables monitoring of chemical reaction in real-time under real conditions. With integrated data acquisition and analysis, and a custom designed flow tube, InsightMR is the perfect solution to complement your vibrational spectroscopy measurements.
The impact of using both NMR and mid-IR spectroscopy during the development of an active pharmaceutical ingredient will be demonstrated.
Who should attend?
Managers, scientists and technicians who are involved in the disciplines of synthetic organic chemistry and process development, both in academic and industrial settings, including:
- Process chemists
- Analytical chemists
- Synthetic organic chemists
- Chemical engineers
- Chemistry and pharmaceutical sciences students
- Regulatory agencies